Metoprolol tartrate, better known by the brand-name Lopressor, is a widely-used beta-blocker usually prescribed to lower blood pressure, manage angina, prevent heart attack, or help regulate heartbeat. Patients also buy metoprolol tartrate to help reduce the frequency and severity of migraines, to prevent or minimize anxiety, and to alleviate side effects from other medications.

The medication works by slowing the rate at which the heart beats while dilating blood vessels, which lowers blood pressure and reduces the heart's workload. It also inhibits the body's ability to utilize adrenaline (also known as epinephrine), which can pose problems for those who rely on epinephrine medically, such as in cases of severe allergic reactions.

Dosage & Administration

Metoprolol tartrate is a relatively slow-acting medication; it takes about a week from the start of treatment to feel the full effects. Likewise modifications to dosage will not be fully realized for about a week. This is true in all uses outside of a hospital setting; it is a maintenance medication, not a "rescue" treatment.

During the first week or two of use, as the body adjusts to a new medication and dropping blood pressure, many patients will feel tired and run-down, both mentally and physically. This is normal and not cause for concern unless severe enough to be disruptive. These symptoms should fade away completely after the first couple weeks of treatment.

Treatment will vary to some extent depending on the condition being treated, its severity, other medications being taken, and individual factors like age and weight. Several dosage adjustments may be required to acheive the optimal outcome. Roughly, however, treatment is typically as follows:

• Treatment starts with 100 mg per day for at least one week.
• Dosage may be increased weekly if needed until desired results are achieved.
• Treatment should not exceed 450 mg per day.
• Doses are usually taken twice per day, though smaller doses are sometimes taken once per day if treating hypertension.
• Tablets should be taken with or immediately following a meal.
• Tablets may be split if they have a score line, but should not be crushed, chewed, or dissolved.
• Treatment may continue for as long as it provides benefit.
• If stopping treatment or switching to a different medication, dosage should be gradually reduced over one or two weeks.

Stopping metoprolol tartrate abruptly can cause rebound hypertension, in which blood pressure rapidly rises, and can contribute to resistant hypertension, in which high blood pressure responds poorly to treatment. Both of these are potentially dangerous situations. Many patients abruptly cease taking medication due to intolerable side effects. If experiencing disruptive or worrisome side effects from metoprolol tartrate, it is advisable to speak with a doctor before discontinuing treatment.

Important Precautions

Metoprolol tartrate is not the ideal treatment for everyone; some individuals are at increased risk of potentially serious complications. Before you buy metoprolol tartrate consider that:

• Beta-blockers may mask symptoms of hypoglycemia and hyperthyroidism.
• Beta-blockers are not recommended in patients with chronic breathing ailments, such as asthma or COPD.
• Beta-blockers inhibit the body's response to epinephrine. This can cause issues in those dependent on epinephrine to manage other conditions, as well as reduce effectiveness in emergency use of epi-pens for anaphylactic shock or when administered in severe asthma attacks.
• Patients who have poor circulation are at greater risk of experiencing circulation complications.

Patients to whom the above conditions apply should discuss the risks of metoprolol tartrate use carefully with a doctor before initiating treatment; there are many alternative options available which may prove less risky.

Also note that the medication can change the way patients react to anesthesia. It is important that doctors be notified beta-blockers are being taken prior to surgery, including dental surgery.

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